The 1960 United States presidential election in Missouri took place on November 8, 1960, as part of the 1960 United States presidential election. Missouri voters chose thirteen representatives, or electors, to the Electoral College, who voted for president and vice president.
In the nation's third-closest race, Missouri was won by Senator John F. Kennedy (D–Massachusetts), running with Senator Lyndon B. Johnson, with 50.26% of the popular vote against incumbent Vice President Richard Nixon (R–California), running with United States Ambassador to the United Nations Henry Cabot Lodge, Jr., with 49.74% of the popular vote. As of the 2016 presidential election, this is the last election in which Osage County voted for the Democratic candidate. This is also the most recent election when a Northern Democrat carried Missouri, as the next three Democratic presidential candidates to win the state were all from the South (Lyndon B. Johnson was from Texas, Jimmy Carter from Georgia, and Bill Clinton from Arkansas), though Northern Democrat Barack Obama from nearby Illinois came very close to carrying the state in 2008, with losing it by only less than a percentage point.