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AliasesWNT3A, Wnt family member 3A
External IDsOMIM: 606359 MGI: 98956 HomoloGene: 22528 GeneCards: WNT3A
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for WNT3A
Genomic location for WNT3A
Band1q42.13Start228,006,998 bp[1]
End228,061,271 bp[1]
RNA expression pattern
PBB GE WNT3A gnf1h01091 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 1: 228.01 – 228.06 MbChr 11: 59.25 – 59.29 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Protein Wnt-3a is a protein that in humans is encoded by the WNT3A gene.[5][6]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis, adipogenesis etc[7] and in several other developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154342 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000009900 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Saitoh T, Hirai M, Katoh M (Jun 2001). "Molecular cloning and characterization of WNT3A and WNT14 clustered in human chromosome 1q42 region". Biochem Biophys Res Commun. 284 (5): 1168–75. doi:10.1006/bbrc.2001.5105. PMID 11414706.
  6. ^ a b "Entrez Gene: WNT3A wingless-type MMTV integration site family, member 3A".
  7. ^ Kennell, Jennifer A.; MacDougald, Ormond A. (24 June 2005). "Wnt Signaling Inhibits Adipogenesis through β-Catenin-dependent and -independent Mechanisms". Journal of Biological Chemistry. 280 (25): 24004–24010. doi:10.1074/jbc.M501080200. PMID 15849360.

Further reading[edit]