A Fellow of Wadham College, Oxford at the time of the Parliamentary visitation of 1648, he compromised sufficiently to retain his position, and was appointed chaplain to John Lovelace, 2nd Baron Lovelace. Later he succeeded John Wilkins as Warden of Wadham College from 1659 to 1665. He was Vice-Chancellor of the University of Oxford in 1662, and succeeded in establishing a degree of calm after the turbulence that had accompanied the Restoration of 1660.
He became Bishop of Oxford in November 1665 (his appointment being the first announcement in the first edition of the Oxford Gazette, later the London Gazette), and Bishop of Worcester in 1671. He was also appointed Clerk of the Closet in 1668 (until 1669) and Dean of the Chapel Royal in 1669, serving until 1675.
He also had a distinguished series of positions as chaplain, first with John Lord Lovelace. He served as chaplain to Sir Edward Hyde, later the Earl of Clarendon and highly influential statesman. He was also one of the bishops brought into the household of Hyde's daughter, Anne, Duchess of York. Following in this position George Morley, Blandford had no more success than others in heading off the Duchess’s ultimate conversion to Catholicism.
- Cooper 1886.
- Wardens of Wadham, Wadham College, Oxford, UK.
- "Previous Vice-Chancellors". University of Oxford, UK. Retrieved 29 July 2011.
- James William Johnson, A Profane Wit: The Life of John Wilmot, Earl of Rochester (2004), note 4 p. 364, note 30 p. 390.
- "No. 1". The Oxford Gazette. 7 November 1665. p. 1.
- J. R. Henslowe, Anne Hyde, Duchess of York (1915?), p. 293; online text.
| Warden of Wadham College, Oxford
| Vice-Chancellor of the University of Oxford
|Church of England titles|
| Bishop of Oxford
| Bishop of Worcester