ZNF217

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
ZNF217
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesZNF217, ZABC1, zinc finger protein 217
External IDsOMIM: 602967 MGI: 2685408 HomoloGene: 4757 GeneCards: ZNF217
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for ZNF217
Genomic location for ZNF217
Band20q13.2Start53,567,065 bp[1]
End53,609,907 bp[1]
RNA expression pattern
PBB GE ZNF217 203739 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006526

NM_001033299
NM_001159683

RefSeq (protein)

NP_006517

NP_001028471
NP_001153155

Location (UCSC)Chr 20: 53.57 – 53.61 MbChr 2: 170.11 – 170.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein 217, also known as ZNF217, is a protein which in humans is encoded by the ZNF217 gene.[5][6]

Function[edit]

ZNF217 can attenuate apoptotic signals resulting from telomere dysfunction and may promote neoplastic transformation and later stages of malignancy.[7] Znf217 was shown to be a prognostic biomarker and therapeutic target during breast cancer progression.[8]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171940 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052056 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Collins C, Rommens JM, Kowbel D, Godfrey T, Tanner M, Hwang SI, Polikoff D, Nonet G, Cochran J, Myambo K, Jay KE, Froula J, Cloutier T, Kuo WL, Yaswen P, Dairkee S, Giovanola J, Hutchinson GB, Isola J, Kallioniemi OP, Palazzolo M, Martin C, Ericsson C, Pinkel D, Albertson D, Li WB, Gray JW (Jul 1998). "Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 95 (15): 8703–8. doi:10.1073/pnas.95.15.8703. PMC 21140. PMID 9671742.
  6. ^ "Entrez Gene: ZNF217 zinc finger protein 217".
  7. ^ Huang G, Krig S, Kowbel D, Xu H, Hyun B, Volik S, Feuerstein B, Mills GB, Stokoe D, Yaswen P, Collins C (Nov 2005). "ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction". Human Molecular Genetics. 14 (21): 3219–25. doi:10.1093/hmg/ddi352. PMID 16203743.
  8. ^ Littlepage LE, Adler AS, Kouros-Mehr H, Huang G, Chou J, Krig SR, Griffith OL, Korkola JE, Qu K, Lawson DA, Xue Q, Sternlicht MD, Dijkgraaf GJ, Yaswen P, Rugo HS, Sweeney CA, Collins CC, Gray JW, Chang HY, Werb Z (Jul 2012). "The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression". Cancer Discovery. 2 (7): 638–51. doi:10.1158/2159-8290.CD-12-0093. PMC 3546490. PMID 22728437.

Further reading[edit]

External links[edit]